The effects on growth and reproductive function by parabens in <i>C. elegans</i>

In recent years, paraoxybenzoic acid esters (parabens) have been used in pharmaceuticals, cosmetics, and food additives. Parabens reported to a weak estrogenic effect vitro test systems, it is presumed that the longer alkyl chain of paraben, greater its endocrine-disrupting reproductive function effects. However, effects parabens on human health are still unclear. this study, we evaluated six (methyl p-hydroxybenzoate [MP], ethyl [EP], propyl [PP], isopropyl [IPP], butyl [BP], isobutyl [IBP]) model organism Caenorhabditis elegans. We 25, 50, 100 µg/mL solutions 0.1% dimethyl sulfoxide (DMSO). Bioassays (growth maturation tests reproduction tests) were performed L1 larvae wild-type C. growth test, all observed no effect. there was significant decrease maturity at each concentration five parabens, with exception being MP. number lifetime offspring EP. This remarkable PP, which has adversely affect rats. It necessary continue focus estrogen-like action including perform genetic analyses, such as RNA sequencing.